I would also like to be in charge! I am very interested in taking this hill! We march at dawn! This is why I can digest counsel to ramp it up easier than settle down. It is in keeping with how I am wired. Vancomycin still has use in a clinical setting, as many strains remain susceptible to it, but vancomycin-intermediate S aureus (VISA) and vancomycin-resistant S aureus (VRSA) strains have been reported. 8,9 What is community-associated MRSA (CA-MRSA)? Although MRSA infections were predominantly found in the hospital or clinical setting (HA-MRSA), there are now an increasing number of outbreaks of MRSA in community settings, in people who were otherwise healthy, and this has led to the term community- associated MRSA (CA-MRSA) being used. These outbreaks appear to be linked to strains that have some unique properties not seen with HA-MRSA strains. They are usually more virulent and spread more easily, cause skin and soft-tissue infections, but are commonly less resistant to antibiotics and easier to treat than HA-MRSA. Some strains of MRSA produce the Panton-Valentine leukocidin (PVL) toxin, which can cause very serious infections. 10 PVL is frequently detected in isolates of CA-MRSA obtained from infections in previously healthy children and young adults. 11 The toxin destroys white blood cells and tissues, causing extensive tissue necrosis and spreading infection. Recent research has demonstrated that overproduction of substances termed phenol-soluble modulins (PSMs) could be the main virulence factor in certain strains of CA-MRSA. 12 PSMs are bacterial proteins that can cause a potentially fatal immune reaction called a cytokine storm, which rapidly kills white blood cells and immune cells. To a certain extent, we're getting exactly what we asked for--magic potions from doctors. Yes, our care costs more, but we want the potions. Then we complain about the ramifications and subsequent cost increases associated with our own demands. According to a 2017 study by the Kaiser Family Foundation, the United States has the highest rate of preventable deaths from heart attack, stroke, diabetes, cancer, overdoses, and suicides. So many things in our lives seem out of our hands--nuclear bomb threats, terrorist attacks, school shootings, horrible genetic diseases, car accidents.
And yet we're not acting on the controllable factors in our lives. It's beyond shocking. I am proud to be an American. I might not be proud of every detail of our history, but I love our founding principles. I'm grateful that I was not born in an oppressed nation and that I was given every opportunity not only as a female but also as a single teenage mother. (Note to self: Speak to counselor about historic struggle with church definition of womanhood. Could be related. Maybe not a mystery. ) Let's talk about you. I suspect you have experienced frustration if you've been urged to fill the wrong container. Think through leaders you follow, in real life and online. If their messaging consistently makes you feel either hamstrung or exhausted, could it be they are leading out of their personal volume but it doesn't match yours? Or maybe it is your boss, coworker, employee, or friend. People typically engage from their own capacity and its corresponding practices, which is why I opened this article with a story as a Mega forced to deflate, then spent one thousand words lamenting the muzzling of women before turning to you like, Oh. The main criteria differentiating HA-MRSA infections from CA-MRSA infections are that the latter are acquired by persons who have not been hospitalised within the past year, nor undergone invasive medical procedures such as dialysis, surgery, venous or urinary catheterisation. CA-MRSA is most often seen as skin or soft-tissue infections (SSTIs) such as boils or abscesses, but can cause more serious health problems, such as bloodstream infections or pneumonia. Patients often describe having had what looked like a 'spider bite' before becoming ill. The involved site is red, swollen and painful and may produce yellow pus. The wound may break open or fail to heal and may develop into an abscess.
In some cases, CA-MRSA can rapidly lead to widespread and potentially fatal infection. A number of CA-MRSA strains have been found in the United States; the three most common are named USA-100, USA-300 and USA-400. CA-MRSA strain USA-300 has also been found in England and Wales since at least 2002, where it is called ST8- SCCmec Iva. There is some evidence to suggest that the USA- 300 strain is more virulent than other CA-MRSA as it produces the PVL toxin13 and is commonly found in HIV-infected patients. And yes, I am proud that I took advantage of my opportunity to be successful. At the same time, I'm saddened when my fellow Americans take advantage of their freedom for the worse. We're living free, and we're living longer, but we're hurting. As people live longer, we are also living longer with chronic illnesses. Even though we shell out more money on health care than any other country in the world, the CDC says that 75 percent of those dollars go toward chronic conditions. Almost half of American adults have a chronic condition. What is even more troubling is that chronic conditions are on the rise among all age groups, not just adults. One in five adults has arthritis--the most common cause of disability in America--which is largely linked to lifestyle and weight. Children have higher obesity rates than ever before. 4 Consequently we're seeing a huge rise in teenagers with type 2 diabetes. Hi. I didn't see you there. Even as a big-space type, I have my limits. I follow a couple of influencers whose every post is about trying harder, becoming better, dreaming bigger, and running faster. Look, I love to try, become, dream, and run (metaphorically, omg), but even I finally throw my hands up and scream, NOPE.
TODAY I WILL LIE ON THE COUCH AND WATCH FOOTBALL AND EAT CHIPS. The only dream I will have today is during my nap. I can imagine how draining this do-more tidal wave is for the lower-key Mezzos and Modests. However, it has an unbelievably positive effect on most Megas. Maybe you need a big container to hold all your stuffings, but your community or work environment or home life prefers less volume. The USA-300 strain is genetically related to an HA-MRSA strain, which emerged in the 1960s in Europe, after the introduction of methicillin. Both of these strains are thought to be descendants of a methicillin-susceptible ancestral strain. Bacteria and other micro-organisms can attach to the surface or interface of inanimate objects and develop highly complex structures called biofilms, composed of sticky polymers produced by the bacteria. It has been estimated that biofilms are responsible for more than 80% of all infections, many of which are of nosocomial origin, meaning that they were acquired in a hospital or clinical setting. 15 A common example of a biofilm is the tartar plaque found on teeth. The bacteria within the biofilm matrix interact and function as a unit rather than as individual cells, and chemical signalling processes attract other bacteria. Biofilms offer a protective shield for the microbes, and bacteria in this state are more able to resist antibiotic therapy. Biofilms are a significant problem with catheters, prosthetics, pacemakers, artificial heart valves, dentures and contact lenses. Many chronic infections caused by S aureus and MRSA are aided by their ability to adhere to medical devices and form a biofilm. When S aureus grows in a biofilm it undergoes an adaptive response. Before the obesity epidemic in our country, type 2 diabetes was practically unheard of in people under 30; that's why it was formerly called adult-onset diabetes. Reports from the CDC predict that one in three children born in the year 2000 in the United States will develop type 2 diabetes in their lifetimes unless there are significant changes in diet and physical-activity levels. We are living in an obesogenic environment of processed and fast food, and it is taking its toll on children. Schools are not placing enough importance on physical education and activity.
Parents can easily sign a waiver for their child to opt out of any physical activity during school for various reasons. When children are at home, parents are too afraid to let them play outside or climb a tree or walk or ride bikes on their own. Children (like their parents) are glued to their devices. The massive influx of screen technology has also created newly recognized forms of depression and anxiety and pushed children and adults alike further from direct human interaction and physical activity. We are afraid to call out problems of obesity and sedentariness because we are afraid of being considered prejudiced or mean. Megas and high-octane Mezzos famously push the envelope in traditional spaces that venerate homogeny, patriarchy, politeness, or the status quo. Shouldering the inevitable disapproval is so discouraging. The only way to shove a square peg in a round hole is to lose the edges, and the big-space types were born with edges. There is nothing more life-giving than an environment that matches your volume. It is hard to put a price on being seen and valued as you are. When you don't have to ratchet down or falsely inflate but are welcomed with your contents exactly intact, this is when we thrive. I operate in several of these environments, and my big feelings (would I have any other kind? ) explode with gratitude. I was born to parents who still believe we were all mislabeled prodigies, I married a man who thinks I should run the country, and I lead in a church that champions lady preachers. My chosen environment never asks me to simmer down. Genetic analysis has identified 48 genes that are induced (switched on) and 84 genes that were repressed (switched off,) during biofilm growth compared to planktonic (free-floating) growth. 16 Experiments on the polysaccharide polymers produced by MRSA indicate that biofilm development involves a protein, regulated by genes involved in the adaptive response. Concentrations of carbon dioxide, oxygen and glucose appear to be triggers for biofilm development, although different mechanisms of biofilm production have been recorded in MSSA (methicillin-sensitive) and MRSA clinical isolates. Can MRSA be controlled? The emergence and increasing occurrence of MRSA and other antibiotic-resistant bacteria have encouraged the exploration of novel methods of treatment.