Tuesday, 9 June 2020

How to Change Your Paradigm?

After Beck made her deposit, fertility experts said, for the record, that they hoped medical technology would advance by the time she needed to thaw her eggs. Off the record, they said the girl was banking on a pipe dream. Each 10-minute workout consisted of just two all-out 10- to 20-second sprints. The results demonstrated a significantly larger aerobic effect in the REHIIT group, even with only one-fifth of the time spent exercising. Additionally, studies have also found significantly improved metabolic, cardiovascular, and fitness benefits in as little as six HIIT sessions performed over two weeks. A 2010 study published in Metabolism showed beneficial changes to insulin sensitivity, maximal oxygen uptake, systolic blood pressure, and waist and hip circumference in overweight sedentary men. This is amazing new science and very exciting stuff. Exercise for health and fitness used to be about time invested, but now it's more about the intensity level. The time needed for an effective workout keeps shrinking. Research suggests that HIIT may undo some of the aging process. A Mayo Clinic study compared participants aged 64 to 80 to those aged 18 to 30. Subjects exercised three times a week for 12 weeks in one of three ways: HIIT exercise, vigorous upper- and lower-body weight training, and a combination of moderate-pace cycling and light weight training (MICT). This is a article that, first, foremost, and through most of its articles, clarifies the destination. True, once you know where you want to go, tools like GPS make getting there a whole lot easier. So, too, for eating well. There are tools for eating well that make the simple truths easier to translate into practice. We will end with those. But the first order of business is establishing where there is. Knowing where there is, is prerequisite. You have no hope of getting there from here if you don't know where there is.

The truth about food is stunningly simple. It's the lies that are complicated . It's hard to tell a woman diagnosed with tongue cancer twice not to count on modern technology. Beck knew the doctors were pessimistic. At my first American Society of Reproductive Medicine meeting I said I froze my egg and the doctors said to me, `you made a mistake, you mean you froze your embryos. I went home crying. Today, egg freezing has gone the way of all new reproductive techniques, from a bizarre idea to a commercial enterprise. Everybody is in the business--there are labs across the United States, Italy, South Korea, Australia, Japan, and Israel. The skeptics five years ago are now among some of the industry's greatest devotees. Thawing has improved, but it's far from perfect. Like sperm, no one is keeping track of the numbers, and so statistics are murky. Experts say upward of 1,000 babies have been born from frozen eggs. The study found that HIIT robustly improved cardio-respiratory fitness, insulin sensitivity, mitochondrial respiration, and fat-free mass in both age groups. The researchers also biopsied the muscle cells of the participants. According to some estimates, these muscles get steadily weaker after our mid-40s and don't regenerate easily. Amazingly, it was discovered that, by far, the largest number of gene changes occurred in the 64- to 80-year-old age group that participated in HIIT exercise. HIIT robustly increased gene expression, particularly in older adults. HIIT also had robust increases in transcriptional and translational regulation of muscle growth and mitochondrial pathways. These results mean that the researchers discovered that the older people who participated in HIIT had cells with a significantly improved ability to regulate and control their own activity, which in turn resulted in improved cellular health. In addition, the mitochondria (the energy producers of the cell), which normally diminish as we get older, grew healthier and increased in numbers by almost 70 percent.

The HIIT group experienced the greatest overall health and fitness gains, including increased muscle strength and the strongest gains in endurance. In addition, the 64- to 80-year-old HIIT participants had, by far, the most dramatic changes in cellular health. My hope is that this article will offer unique value to you by uniquely, so far as I know, addressing both comprehensively. Why waste time on the lies? Wouldn't it suffice to address the truth - which would then indicate that everything else is something other than truth, lies or something like them? I don't think it would suffice. I have made such attempts before myself, notably in my first article for the general public, The Way to Eat . I have repeated the effort in subsequent articles. The truth has been told many times, in many ways, but has not defended us from lies. What has become increasingly clear to me over time is that lies about diet are quite good at impersonating truth. If anything, the lies are more appealing, since they are unencumbered by inconvenient tethers to evidence. Lies can promise anything, while the truth can only promise . Though it is still considered experimental and success rates are depressingly low, triumphant stories that hit the press every so often are beginning to lure women, each paying upward of thousands of dollars, each gambling on an imperfect science. Curiously, the vast majority of customers are not cancer patients, who originally inspired the research, but healthy single women, like the woman at Yale, who for one reason or another want to put their eggs on ice in a Dorian Grey state as the rest of their bodies confront the inevitable. Haven't found Mr. Perfect yet? Want to focus on a career without waking up in the middle of the night to nurse a newborn? Why not ice an egg and reheat it when the time is just right? The way the marketers tell it, you are better off freezing your own egg than buying a fresh one from a younger woman later on. Of course, regular intercourse may do the trick too, but as fertility experts remind us, you cannot rely on your biological clock.

Who knows, maybe one day we will be able to reset the clock and let it run as long as we need. Let's be clear on one thing. This prompted the author of a study review article, quoting one of the principles of the study, to conclude, It seems as if the decline in the cellular health of muscles associated with aging was `corrected' with exercise, especially if [the exercise] was intense. A telomere is the cap at the end of a chromosome that protects it from damage. Every time a cell divides, the telomeres shorten, exposing the cell to damage. Telomerase is an enzyme that attempts to replenish the shortening telomere and protect the cell from death. HIIT has a positive impact on telomerase, too: A 2014 study reported in the International Journal of Analytical, Pharmaceutical and Biomedical Sciences examined the effects of HIIT exercise on young sedentary women. The women exercised three times per week for eight weeks. In addition to significant decreases in body fat, body mass index, and weight, the women who participated in HIIT saw a significant increase in telomerase activity, and consequently in telomere length. Now that you've suffered through a crash course in genetics, you can see that the benefits of HIIT go to the very depths of your being. They reverse some age-related decline, protect your DNA, and improve the health and longevity of your cells--all the while preventing disease and prolonging your life. If that's not the fountain of youth, I don't know what is! That's a stark disadvantage. The lies can be magical, effortless, and supremely confident. As Bertrand Russell famously noted, The whole problem with the world is that fools and fanatics are always so certain of themselves, and wiser people so full of doubts . Doubts put wise people at a disadvantage, because they have to say terribly inconvenient things like: maybe. Fools and fanatics get to be certain. In much the same way, the truth is at a disadvantage relative to lies. The whole problem with the world is that fools and fanatics are always so certain of themselves, and wiser people so full of doubts . We each presume inevitably that Kipling is speaking to us, and thus that THE truth is OUR truth.

But if everyone is the person to whom Kipling is speaking - if each of us owns the truth - then who is the knave, who twists the truth? Who is the fool taken in by such distortions, willful or otherwise? Egg freezing is not about masturbatoriums filled with photos of sexy men and porn videos. Whether you are freezing eggs to donate to another woman (and getting paid a lot of money) or freezing eggs for your own future use (and paying a lot of money), it is not fun. We're talking about injections of potent hormone drugs that hyperstimulate your ovaries to spew dozens of eggs in a cycle followed by an invasive procedure to retrieve them. While sperm banks are turning eager masturbators away, it takes marketing prowess to encourage women to go this route. The egg is the most amazing cell in the body. They are rare, hard to get to and they are fragile and extraordinarily robust at the same time, explains Dr Teresa K. Woodruff, chief of the Division of Fertility Preservation at the Feinberg School of Medicine, Northwestern University, in Chicago, Illinois. It's a cell of extraordinary contradictions. Woodruff, a renowned basic scientist, is also a professor in the department of biochemistry, molecular biology and cell biology and in the department of obstetrics and the founder of the Oncofertility Consortium. Women start making eggs at 9 weeks of gestation. Over the last 20 years of my medical practice, I've treated thousands of adults who aged from their mid-50s into their 60s and 70s. Many were health conscious and physically active; Without a doubt, those that didn't exercise regularly declined physically and mentally at a much faster rate. And, unfortunately, modern medicine won't necessarily come to the rescue when things fall apart later in life. Though great strides have been made and many lifesaving techniques exist, the quality of life with diabetes, or after suffering a heart attack or getting a joint replacement, isn't always rosy. The side effects of medication often result in a poorer quality of life. Muscle pain and fatigue are common side effects, and some of my patients have had to give up hobbies they love, like gardening and woodworking, because they're on blood thinners and fear cutting themselves. Studies also show that a significant number of people still have pain and are unhappy with their replaced joints following surgery.

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