Thursday, 18 June 2020

Refuse to Flinch

How hot does it get at the peak of summer? When does the frost end in the spring and begin in the winter? If you live in an urban area and plan to plant straight into the soil, you should test your soil for lead before planting. The Soil and Plant Tissue Testing Laboratory at the University of Massachusetts Amherst does it for a small fee. If lead levels are too high, you will need to garden in pots or raised beds that are blocked off from the original soil and filled with new soil. In addition think about your own needs. Fruity, sweet, or matcha teas As you already have learned, a sweet or food-like flavor will stimulate CPIR. So, avoid all these types of tea during the fast and save them for your eating window. What about matcha? Matcha is made from a powder that you mix with water. Rather than brewing the tea leaves and discarding them, you actually consume them. Is that enough to break the fast? I wouldn't risk it. Yes, there is a quantity of matcha powder that would definitely break the fast, and I can't tell you with any certainty what that threshold would be. So, follow the rule of thumb: when in doubt, leave it out. You can't be bored and anxious at the same time. Neurologically speaking, if the brain becomes desensitized to fear-based stimuli, there is no fear. And that is your goal: to overcome anxiety, so it doesn't cause suffering and create a limitation. Your goal is to stop anxiety from interfering with your life, or from being a barrier of any kind.

But to fully achieve this goal, you must achieve brain boredom. So the goal of exposure is not really anxiety reduction, it's really boredom. Anxiety reduction is just a byproduct. Another way to think of the boredom you can achieve with exposure is as indifference. Indifference means you simply don't care. No love or hate, not really even like or dislike. Notably, at the time, pharmaceutical spending was only a fraction of what it is today, so it was not covered. What is perhaps most remarkable about the CHA, however, is how much it omits. Beyond outlining the 5 guiding principles to which provinces must adhere in order to receive federal funding, the CHA leaves everything else to the provinces and territories. This has led to a highly decentralized system--there truly is no single Canadian health care system; But how they realize these values differs sharply. Since the passage of the CHA, the Canadian system has been remarkably stable compared to other nations. On the federal level especially, the CHA's tenets continue to define the Canadian health care system's organizing principles. On the provincial level, a great deal of experimentation, gradual expansion of health benefits, and a gradual--albeit growing--trend toward centralization have characterized the last few decades. Canada is a country of 37 million people. It has achieved truly universal health coverage through a 2-layered system: (1) mandatory basic health insurance provided by a diverse system of provincially administered public insurance programs and (2) a network of voluntary supplemental health insurance provided by private companies. How did you know? I told her about our longevity study and said that centenarians and their families have unusually high levels of HDL cholesterol, especially when compared with their average LDL cholesterol levels. By this point, I was quite comfortable treating this phenomenon as a real indicator of longevity. Are There Really Good Gene Mutations?

After seeing similar cholesterol results in hundreds of centenarians and offspring, we were convinced that whatever was responsible for their differences could be inherited. So we began looking for cholesterol genes that might have significant mutations that were doing good instead of harm. But we ran into some unanticipated resistance from the IRB because the members were concerned about what we would do if we discovered people who had harmful mutations that caused diseases. If we happen to see one, there isn't anything we can do about it. Discovering mutations and variants is exciting, but the findings are given the same weight as the findings of association studies until we can validate them in other populations or do functional studies on cells or animals to prove that the mutations are important. Once we got approval from the IRB for our study, we began looking at a variety of genes that are associated with the creation and transportation of cholesterol, and we discovered that two genes that modulate HDL cholesterol and triglycerides had functional variants, meaning that the genes functioned differently because of the mutation. Are you away for long periods of time during the year? Do you have neighbors who will be willing to care for your garden while you're gone? Where do you walk most often? If you put your garden in the backyard but you're hardly ever there, you probably won't remember to water it. If you want to build those bonds with your neighbors, a garden that's visible from the sidewalk is a better bet. It can be useful to set a time of day to care for the garden. Raising kids is hectic; Whether it's in the morning, after lunch, or when the kids come home from school, having a consistent time makes it more likely you'll remember to do necessary maintenance. Share Your Joy for Gardening, Vegetables, and Learning Enthusiasm can be contagious, especially among small children. You shouldn't need me to tell you this if you read the last article: sweet taste = insulin release. So, you absolutely don't want to consume any diet sodas during the fast. Natural or artificial flavors Our goal is to avoid anything with food-like flavors during the fast, so avoid any products that have either natural or artificial flavors on the ingredients list.

Here's something else that makes natural or artificial flavors so problematic. Food manufacturers hide all sorts of things in foods using the words natural flavors or artificial flavors. You literally have no idea what they might include or how it might break the fast. Save the flavors for your eating window, when you can have any flavor you want. One thing that confuses many people: sweeteners are often marketed as no glycemic response! Glycemic response means that it raises blood sugar. You just don't give one iota. This is what exposure ultimately achieves. Exposure can generate indifference to your fear, so you just don't care and then it's no longer there for you to beware. An easy example of indifference that often springs to my mind is baseball (if you love it, I apologize). I know it's considered the national pastime, but it just does nothing for me. I don't like it or dislike it. I just don't care about it. The World Series could be on TV and I might not know it. If I ever go to a game, I'll enjoy the experience, but not because of the game itself. I'm focused on the food and the fans, not the game. There are also a handful of federally administered programs that care for special populations, including the First Nations and members of the Canadian Armed Forces. Coverage Model All Canadian citizens enroll in one of the 13 provincial or territorial statutory health insurance plans, collectively referred to as Medicare. In accordance with the CHA of 1984, these plans are required to provide all medically necessary services.

This includes all medically necessary hospital care, physician services, diagnostic tests, and inpatient pharmaceuticals. It is ultimately up to the province or territory to define the package, as there is no required list of procedures and interventions that must be covered. All services deemed medically necessary by provinces are both universal and completely free at the point of care. There are no co-payments, no coinsurance, and no balance billing. What is considered to be medically necessary, however, is quite sparse. Dental care, vision care, long-term care, ambulance services, and even outpatient pharmaceuticals are not uniformly covered by every province. And many of our centenarians had one or two genetic variants that affect the clustering of the cholesterol particles: About 18 percent of our centenarians have a specific variant in a gene called cholesteryl ester transfer protein (CETP) that's associated with high HDL and with longevity. This variation inhibits the action of CETP. About 20 percent of our centenarians have a mutation in the APOC3 gene, one of the carriers of HDL cholesterol, in the gene's promoter region--the switch that turns the gene on and off--which results in higher good cholesterol and lower triglycerides. Both of these variations are giving us insights into cardiovascular health and longevity, and we're delighted that our findings have helped two pharmaceutical companies develop inhibitor-type drugs. One of the reasons for failures in drug development is that we assume we know what to expect in humans based on what we learn from mice. For pharmaceutical development, it is important to first find people who have mutations or variants in the gene that the company wants to target. They want to see variants or mutations that either cause a disease or prevent it. Furthermore, if the mutation or the variant causes the exact effect that the company wants to mimic, they will want to see if there are downsides to the variant, so there's a need to gather data on safety. In our case, both variants were more common in centenarians than in the unrelated control group, and that was a good sign that they were safe. What excites you is going to excite them. They will follow your passion, said Studer. She recommends discussing what you like about eating and growing different vegetables. Mshar said that one of her favorite activities in the garden is digging up potatoes.

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